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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
Houpoea obovata (Thunberg) N. H. Xia & C. Y. Wu
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "Houpoea obovata (Thunberg) N. H. Xia & C. Y. Wu" in MCE Product Catalog:
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Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM .
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2 Cited Publications
Synonyms: BMS-986177; JNJ-70033093
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Milvexian is an orally bioavailable, small-molecule, reversible, direct antagonists of factor Xia, with the Ki of 0.11, 0.38, 0.64, 490, 350 nM for human, rabbit, dog, rat, mouse, respectively. Milvexian shows anti-thrombosis activity in vitro and in vivo, and can be used for thrombus study .
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2 Cited Publications
Cat. No.: HY-P81223
Synonyms: Cholesterol 20 22 desmolase antibody
Cholesterol desmolase antibody;
Cholesterol monooxygenase (side chain cleaving) antibody;
Cholesterol side chain cleavage enzyme antibody;
Cholesterol side chain cleavage enzyme mitochondrial antibody;
Cholesterol side-chain cleavage enzyme antibody;
CP11A_HUMAN antibody;
CYP11A antibody;
CYP11A1 antibody;
CYPXia1 antibody;
Cytochrome P450 11A1 antibody;
Cytochrome P450 11A1 mitochondrial antibody;
Cytochrome P450 family 11 subfamily A polypeptide 1 antibody;
Cytochrome P450 subfamily Xia antibody;
Cytochrome P450(scc) antibody;
Cytochrome P450C11A1 antibody;
mitochondrial antibody;
P450SCC antibody;
Steroid 20 22 lyase antibody;
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1 Cited Publications
Cat. No.: HY-N8259
CAS No.: 83864-78-2
Category:
Magnoliaceae Other Diseases Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Houpoea obovata (Thunberg) N. H. Xia & C. Y. Wu
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FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 µM, respectively .
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BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects .
Synonyms: EP-7041
Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research .
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BMS-962212 is a factor XIa (FXIa) inhibitor with a Ki of 0.7 nM against human FXIa and a Ki of 3 nM against rabbit FXIa. BMS-962212 blocks thrombosis while preserving normal hemostatic function. BMS-962212 is applicable to thrombosis-related research .
Cat. No.: HY-P5542
CAS No.: 1251838-01-3
Synonyms: SB-01; Peniel 2000
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Cat. No.: HY-N10587
CAS No.: 65597-47-9
Category:
other families Phenols Plants Disease Research Fields Inflammation/Immunology Pteris multifida Poir. Food Research
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Cat. No.: HY-P4331
CAS No.: 113865-85-3
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Cat. No.: HY-145354
CAS No.: 2488952-56-1
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FXIa-IN-7 is a selective and orally bioavailable factor XIa inhibitor with an IC50 value of 0.4 nM.
Cat. No.: HY-P4332
CAS No.: 113866-16-3
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Cat. No.: HY-150519
CAS No.: 1551460-43-5
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FXIa/Plasma kallikrein-IN-1 is an inhibitor of coagulation factor XIa (FXIa) and plasma kallikrein with Ki values of 187.70 nM and 151.6 nM, respectively. FXIa/Plasma kallikrein-IN-1 can be used in the research of thromboembolic diseases .
Cat. No.: HY-172400
CAS No.: 3046390-69-3
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FXIa-IN-16 (Compound 43) is an orally active and selective Factor XIa (FXIa) inhibitor with an IC50 of 0.19 nM. FXIa-IN-16 exhibits strong anticoagulant and antithrombotic activities and shows good safety in mice. FXIa-IN-16 can be used in the research related to the treatment of thrombosis .
Cat. No.: HY-125856A
CAS No.: 1802426-00-1
Synonyms: BMS-986177 TFA; JNJ-70033093 TFA
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Milvexian TFA (BMS-986177 TFA) is a factor XIa inhibitor with biological activity to prevent venous thromboembolism. Milvexian TFA was effective in reducing the occurrence of venous thromboembolism in patients undergoing knee replacement surgery. Milvexian TFA has good selectivity and shows significant inhibitory effects on plasma kallikrein and trypsin. Milvexian TFA has a bioavailability of 32%, which means it has a high absorption rate in the body. Milvexian TFA showed a relatively low risk of bleeding in clinical trials .
Cat. No.: HY-128889
CAS No.: 1803271-50-2
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FXIa-IN-1 (compound EP-7041) is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor .
Cat. No.: HY-12631
CAS No.: 1004551-41-0
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BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively.
Cat. No.: HY-168712
CAS No.: 3053222-76-4
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FXIa-IN-15 (Compound (S)-10h) is an inhibitor for Factor XIa (FXIa) and plasma kallikrein (PKa) with an IC50 of 0.38 nM and 59.2 nM. FXIa-IN-15 exhibits anticoagulant efficacy, that extends 50% activated partial thromboplastin time (aPTT) with EC1.5X of 0.55 μM .
Cat. No.: HY-E70393J
Bovine Factor XIa is an enzyme, which is involved in the intrinsic pathway of blood coagulation. Bovine Factor XIa is highly selective and exhibits a minimal extended substrate recognition site of at least five residues long. Bovine Factor XIa is reactive as Bovine Factor IXa (HY-E70393I) does, that it cleaves all the peptides bearing factor IX activation site sequences .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
